Clinical trial approved to help the NHS treat COVID-19 patients using plasma

  • A clinical trial has been given approval to determine if plasma donated by patients who have recovered from COVID-19 can help those battling the illness
  • If effective, a scaled-up national programme will deliver up to 10,000 units of convalescent plasma per week to the NHS
  • This would provide enough convalescent plasma to treat 5,000 patients each week

Up to 5,000 severely ill patients with COVID-19 could soon be treated each week with plasma from those who have recovered from the illness as part of a new approach to treating the virus.

The national randomised clinical trial will help to determine if plasma collected from donors who have recovered from COVID-19, known as ‘convalescent plasma’, is an effective treatment for patients who are severely unwell with the illness. Plasma from recovered COVID-19 patients can be transfused to patients who are struggling to produce their own antibodies against the virus.

In parallel with the trial, the government is scaling up the national programme for collecting plasma so the treatment can be widely rolled out if it is shown to be effective. The collection of plasma would be ramped up over April and May to deliver up to 10,000 units of plasma to the NHS every week, enough to treat 5,000 COVID-19 patients per week.

Matt Hancock, Health and Social Care Secretary, said:

This global pandemic is the biggest public health emergency this generation has faced and we are doing absolutely everything we can to beat it.

The UK has world-leading life sciences and research sectors and I have every hope this treatment will be a major milestone in our fight against this disease.

Hundreds of people are participating in national trials already for potential treatments and the scaling up of convalescent plasma collection means thousands could potentially benefit from it in the future.

Professor Jonathan Van Tam, Deputy Chief Medical Officer, said:

The UK is leading the world’s largest trials to find a treatment for COVID-19, with over 7,000 people so far involved testing a range of medicines; we hope to add convalescent plasma to this list shortly.

Convalescent plasma has been used as an effective treatment for emerging infections in the past, and this step forward underpins our science-backed approach to fighting this virus.

Dr Gail Miflin, Chief Medical Officer, NHS Blood and Transplant, said:

As well as continuing to collect enough blood throughout this outbreak, we are also heavily involved in the national research response including major trials of this potential treatment.

We are rapidly building our capability to collect plasma so that we can quickly move into supplying hospitals at scale, should the proposed trial demonstrate patient benefit.

Northern Ireland Health Minister, Robin Swann MLA, said:

Two of the greatest strengths of the UK as we face this emergency are our world-leading health research capacity and the selflessness of our citizens.

The Northern Ireland Blood Transfusion Service and the wider Health and Social Care family are working with their colleagues across the UK to progress and participate in clinical trials on COVID-19.

Minister for Public Health in Scotland, Joe FitzPatrick, said:

The potential for convalescent plasma to aid those suffering from COVID-19 has to be confirmed through clinical trials. I am delighted to see the Scottish National Blood Transfusion Service (SNBTS) and Scottish donors will be playing a key part.

The wellbeing of donors, recipients and staff is a priority so there are strict conditions to protect everyone participating in the trial.

It is also important to recognise that this means that not everyone who recovers from Covid-19 will be able to donate.

Welsh Government Health Minister, Vaughan Gething, said:

I’m very pleased to see clinical trials are now underway and to see Wales sharing expertise with the other UK nations on this programme. It has the potential to significantly improve patient recovery and save lives.

Plasma taken from recovered patients contains antibodies that recognise the virus and can reduce its growth. We will be using plasma from patients at least 28 days after recovery as by that time, antibody levels will have increased.

NHS Blood and Transplant will contact people in England who have recovered from confirmed COVID-19 infection and could be a possible plasma donor, and the plasma will be collected at their centres. Blood will be taken from donors from one arm, which is circulated through a machine that separates out the plasma, and returned into the other arm. The process takes about 45 minutes and provides 2 units of plasma per donation, which can also be frozen and stored ahead for any future need.

Convalescent plasma was used as an effective treatment during the SARS outbreak.

If people have a confirmed positive test result and they are willing to donate, they can also provide details to us through NHSBT’s website.

  • DHSC is working in collaboration with NHS Blood and Transplant and the other UK blood services, Public Health England and NHS Digital to deliver the programme.

  • Ongoing national clinical trial as part of REMAP-CAP – with the possibility of another trial later on if the results of the first trial are shown effective will investigate whether transfusions may improve a patient’s speed of recovery and chances of survival.

  • We will be prioritising donors who are best placed to help so we there may be a short delay in responding to some people.




Communities Secretary welcomes response to his call for parks to open

  • More than 340 parks and green spaces reopen across the country in the last week
  • Communities Secretary stresses that people must continue to follow guidance on social distancing

He welcomed the reopening of parks across the country following his request at last Saturday’s Downing Street press conference, while stressing that people must continue to observe social distancing. 

Parks reopened in the last week include around 340 parks and green spaces in East Devon, Central Park in Boston, Lincolnshire, Himley Park in Dudley, West Midlands, and Cusworth Park in Doncaster.

A survey by the National Federation of Parks and Green Spaces has shown that of 90% of Friends of Parks groups, which help maintain parks across the UK, have reported that all parks in their area remain open, while in areas with some closures they report that 90% of local parks are open.  

Last weekend, the Communities Secretary called for more parks to be reopened to the public for the health of the nation while ensuring people continue to observe social distancing guidelines. He also asked councils to keep open or reopen cemeteries and graveyards, for people to be able to seek solace at the gravesides of those they love.

Communities Secretary, Rt Hon Robert Jenrick MP said:

While the virus does not discriminate, we know that the lockdown is much harder for people who don’t have a lot of living space, a garden, or anywhere for their children to run around. People need parks. 

I’m grateful for the work of councils who have ensured, ahead of this weekend, that most parks across England are now open and cemeteries and graveyards in their area are also open for visitors. We’ll continue to work closely with them to try to get the remaining parks open soon, wherever possible.  

Importantly, I want to stress that we must all continue to play our part in the national fight against coronavirus by continuing to observe social distancing when we exercise in parks.

Chair of the National Federation of Parks and Green Spaces, Dave Morris, said: 

We welcome the government’s public recognition of the continuing vital importance of parks for the health and wellbeing of all our communities.

As the voice of the movement of over 7,000 local Friends of Parks groups we have been aware of widespread calls throughout the entire country for weeks for clarity on this matter.” 

Chair of the Parks Alliance, Matthew Bradbury, said:

We welcome the Minister’s announcement and encourage councils to work with the government to keep parks open. It is well proven that parks provide considerable health and wellbeing benefits to all that use them.   

During this crisis parks are enabling people to stay healthy across the country whilst following the government’s guidance on social distancing. For those without gardens local parks have never been more important.

Under government guidance to help fight coronavirus, people should only leave the house for very limited purposes, including taking one form of exercise, like running or walking. People should also only use open spaces near their home wherever possible, to avoid unnecessary travel.  

Most councils have kept parks open while adapting to keep people safe by taking extra precautions like putting up signs to help people keep two metres apart while they take their daily exercise.  

Local Government Minister Simon Clarke MP has also written to councils this week about ensuring people have access to parks and cemeteries.

The government is updating its guidance to make it clear that burial grounds and cemeteries, grounds surrounding crematoria and gardens of remembrance may remain open.

  • The government’s priority is to save lives and the best way to protect yourself and others from illness is to stay at home. However, exercise is still important for people’s physical and mental wellbeing, for the government has said people can leave their homes for exercise once a day.

  • People should follow guidance to stay local and use open spaces near to their home where possible, avoiding unnecessary travel. You should only go outside along or with members of your own household and should always keep at least two metres apart from anyone outside your household.

  • Gatherings of more than two in parks or other public spaces have been banned and the police will enforce this. Dog walkers should also walk their dogs on a lead in areas used by other people.

  • The survey by the National Federation of Parks and Green Spaces can be viewed online




Tackling COVID-19 and transitioning to peace in Sudan

Thank you, Mr President, and let me begin by thanking Under-Secretary-General DiCarlo and Lacroix and for their briefings. Let me also reiterate the United Kingdom’s condemnation of the attack and the attempted assassination on Prime Minister Hamdok.

Mr President, regrettably, Sudan, as with many parts of the world, is experiencing COVID-19, which comes on top of an already difficult socio-economic and humanitarian situation. On behalf of the United Kingdom, I want to send today a message of solidarity and support to the Government and people of Sudan in their efforts to respond to COVID-19 and mitigate its effects. As part of the United Kingdom’s $1 billion commitment since the COVID-19 outbreak began, we have given $6 million to the UN COVID-19 response plan for Sudan.

Mr President, one of the brightest spots on this Council’s agenda has been the beginning of Sudan’s transition to a democratic and peaceful nation. There has been much progress in the years since the removal of former President Bashir. And we encourage all Sudanese parties, as well as the international community, to remain fully committed behind Sudan to the successful implementation of the constitutional declaration, even during the challenges presented by COVID-19. And let me at this point particularly commend the positive role that the African Union has played and continues to play in Sudan’s political transition.

Mr President, the Government of Sudan and a number of armed movements have been engaging in talks for comprehensive peace across Sudan. That commitment to peace is promising, as is the positive response to the Secretary-General’s call for a global ceasefire by the parties to the Juba peace talks. But we now need to see all sides – in particular, the armed movements – engage constructively, immediately and without preconditions to conclude swiftly the negotiations on a comprehensive peace agreement. We call on them to do so.

Mr President, despite the positive progress has been made in Sudan, we remain concerned by the security situation in Darfur, which continues to be undermined by ongoing conflict in Jebel Marra, increasing levels of inter-communal violence and civilian displacement. Just this week, there were reports of an attack on a village in central Darfur, in which civilians were apparently killed and wounded, 70 homes burned down, and approximately 155 households displaced. The approximately 1.8 million internally displaced persons in Darfur remain particularly vulnerable to human rights violations and abuses. We cannot ignore the considerable challenges which remain in Darfur on and over the protection of civilians.

The United Kingdom fully supports the Government of Sudan’s request for a new, whole of Sudan UN mission that can provide support across the full range of issues related to the transition. We believe that this Council should support this request and a relationship between Sudan and the United Nations, underpinned by national ownership, partnership and collaboration. We should be ready to move quickly in response to Sudan’s declared needs. As Rosemary DiCarlo said today, the situation is dire.

We understand that the Government of Sudan would like the United Nations to support capacity-building, and we in the United Kingdom think that within this, there should be a role for capacity-building, training and mentoring also of police forces. In the time it takes to implement such capacity-building, we must ensure that a security vacuum does not fall and undermine efforts to achieve a comprehensive peace in Darfur, as well as the overall political transition in Sudan. And in a spirit of the new relationship between Sudan and the United Nations, we firmly believe that the new mission can and should be a partner to the Government of Sudan in responding to the ongoing protection of civilians’ challenges in Darfur, particularly in the IDP camps. So I’d like to ask Under-Secretary-General Lacroix for his assessment of the protection of civilians needs and risks in Darfur and the current capacity of the Government of Sudan to assume full responsibility for protection of civilians in Darfur. I would also be grateful if he could provide information on the type of deployment that would be required for the new mission to provide support to the government of Sudan on protection of civilians.

Let me also say we’ve taken note of the measures taken by the United Nations concerning peacekeeping, in particular the pause on rotations. And we understand the impact that this and, as Under-Secretary-General Lacroix also mentioned, around climatic conditions. We understand the impact that these will have on the timings of the planned drawdown of UNAMID.

Mr President, let me conclude by once again reaffirming the United Kingdom’s support for the government and people of Sudan in their endeavours for a peaceful, stable, prosperous and democratic future. We look forward to working with our colleagues in the Council to play our part in supporting those efforts.

Thank you very much.




Delivering on health, safety and justice in Kosovo

Thank you, Mr President.

I would like to begin by thanking the Special Representative and his team for their continued commitment and dedication to Kosovo, as laid out in the comprehensive report on the activities of the UN’s Mission in Kosovo. I would also like to extend my thanks to His Excellency the Foreign Minister of Serbia and His Excellency the Foreign Minister of Kosovo for their briefings this morning.

The situation in Kosovo in 2020 is very different to that of 1999, when UNMIK started its work. UNMIK has played a key role in that transformation. Together with the European Union, OSCE and NATO, it has promoted security, stability and respect for human rights, not only in Kosovo, but in the region more widely. However, significant challenges remain and it is important that UNMIK’s efforts are carefully tailored to address these. We continue to support a review of UNMIK to ensure that it is able to meet current needs as effectively as possible.

Dealing with COVID-19 has to be the primary task of the incumbent Government in Kosovo, as indeed it is for Serbia and other governments throughout the world. The UK stands with the people of Kosovo during this global crisis. This is not a time for political manoeuvring, but cooperation, domestically and regionally. Following the vote of no confidence in the Prime Minister by the Assembly of Kosovo, we call upon all actors to continue to respect the Constitution, and for decisions to be taken quickly to enable the incumbent or new Government to make protection of citizens’ lives the paramount consideration. We welcome the support the UN is providing the Government of Kosovo to help deal with the crisis through the establishment of an inter-agency task force, to support the procurement, and coordinate supplies of medical equipment. We urge that action be taken forward quickly.

Mr President, there have been many positive examples of different communities working together to deal with COVID-19. This Council should welcome the cooperation we have recently seen between the Minister of Health and the Minister of Communities and Returns, and the Mayors of North and South Mitrovica on issues relating to the Kosovo-Serb community. We should also welcome and encourage cooperation between health ministries in Kosovo and Serbia, such as the recent virtual meeting held between Ministers in both countries to discuss their response to the crisis. I would to thank the Italian Ministry of Foreign Affairs for making such a constructive exchange possible. We hope that these actions will solidify the foundations for closer cooperation both within Kosovo, and between Kosovo and Serbia, over the pandemic and thereafter. Access to information on COVID-19 is essential. To that end, we welcome the Kosovo Government’s development of a multi-language website and ask that they ensure that all information related to COVID-19 is available in all official languages of Kosovo.

I echo the Secretary-General’s report in welcoming developments in this period to increase connectivity between Kosovo and Serbia. The normalisation of relations between Kosovo and Serbia remains crucial for regional stability and prosperity and is in the interests of both countries. I reiterate the UK’s long-standing support for the EU-facilitated Dialogue as the route to achieving a legally binding, comprehensive and sustainable agreement between Kosovo and Serbia. We welcome the decision of the incumbent Government of Kosovo on 1 April to lift the tariffs on goods from Serbia and Bosnia and Herzegovina. We call on Serbia to respond positively, and to halt its de-recognition campaign. We believe grievances, including non-tariff barriers, can be settled in the framework of the EU-facilitated Dialogue, if there is the political will and courage to do so. We look to both parties to take the necessary steps to return to the Dialogue at the soonest possible opportunity.

I would like to take this opportunity to welcome the appointment of Miroslav Lajcak as the EU Special Representative for the Belgrade-Pristina Dialogue and other Western Balkans issues. We look forward to working with him, with our Quint partners, and with Serbia and Kosovo, to achieve a comprehensive, conclusive, legally binding normalisation agreement that respects territorial integrity, is acceptable to the citizens of both countries, and will deliver long-term benefits to them and the whole region.

Mr President, we welcome the progress made by the Kosovo Specialist Chambers and Specialist Prosecutor’s Office. The UK strongly supports these institutions and the important work that they do. We urge the Governments of Kosovo and Serbia and the members of this Council to cooperate fully with them. Justice must be delivered for victims and their families. We cannot allow a culture of impunity to exist for the most serious crimes; to do so would be unconscionable: it would be enormously damaging for rule of law and prospects of reconciliation across the region. We regret the slow progress in domestic prosecutions for war crimes, and urge the authorities in Kosovo and Serbia to push ahead in dealing with these historic crimes.

We welcome the progress made by the Government of Kosovo in dealing with the legacy of conflict-related sexual violence, with the first indictment filed by a local prosecution for conflict-related sexual violence as a war crime. We commend the work UNMIK has done in supporting survivors to share their stories and encouraging the Government of Kosovo to prioritise addressing sexual violence. The UK is committed to supporting victims and preventing sexual violence in all its forms. Through funding the ‘Be My Voice’ campaign in Kosovo, we are raising public awareness and tackling head-on the stigma experienced by victims.

Mr President, last October, the people of Kosovo voted for change. They voted for a government that promised to tackle corruption and promote economic development. There is still considerable work to be done to strengthen the rule of law and deal with weaknesses in the justice system in Kosovo. We call upon the incumbent or new Government to prioritise work to deliver the people’s long-term priorities.

In closing, I would like to reiterate my thanks to the Special Representative and his team. We look forward to continuing to support them in their important work.




UK announces 9 more charter flights from Pakistan to return thousands of stranded Brits

Almost 5,000 British travellers in Pakistan are to be brought home to the UK following the announcement today of a further nine Government-chartered flights.

These will include the first UK charter flight from Karachi, which will depart on 30 April, in addition to further departures from Islamabad and Lahore.   

Around 2,500 people have already booked on to the ten Government charter flights that are taking place between April 21 – 27. This second phase of flights announced today will carry more than 2,250 travellers.

The new flights are as follows: 

  • 30 April: Karachi to London, Islamabad to Manchester
  • 1 May: Lahore to London, Islamabad to Manchester
  • 2 May: Islamabad to Manchester, Lahore to Manchester
  • 4 May: Islamabad to London
  • 5 May: Lahore to Manchester, Islamabad to Manchester

There has been a huge demand for these flights, with seats for Lahore and Islamabad now being allocated to those already registered via the Government’s online booking website – CTM.

The portal is now open for those who would like to book on the Karachi flight. Anyone who would like to return to the UK from Karachi should register their interest on the portal as future flights will be based on waitlists.

Foreign Secretary, Dominic Raab said:

With commercial flights back from Pakistan scaled back at the moment, we have chartered a further nine more flights to help get stranded British travellers home.

This will help thousands of British nationals get back home to their loved ones.

FCO Minister of State for South Asia and the Commonwealth, Lord (Tariq) Ahmad of Wimbledon, said:  

Thousands more British nationals in Pakistan will now be able to fly home following the announcement of these nine extra flights, which include our first from Karachi. They will join more than 10,500 people who will have already flown home from Pakistan on commercial options and more than 2,500 on charter flights.

This remains a hugely challenging logistical operation. I am grateful for the cooperation of the Pakistani authorities, the patience of the British people we are working to help, and the hard work of those making it happen.

British High Commissioner to Pakistan, Christian Turner, said:  

More than 10,500 people have returned home by commercial routes since airspace in Pakistan closed, and by Monday we expect that a further 2,500 British Nationals will have flown back to the UK on our first 10 charter flights.

We know there is more to do, and I’m pleased that there will be a further nine chartered flights next week; eight from Islamabad and Lahore; and one from Karachi to London Heathrow.

As we start the holy month of Ramazan, a time for people to reunite with their families and a time for reflection, I am glad that travellers will be able to make it home and be with their loved ones at this special time.

Guidance on how to book onto a government charter flight back to the UK

Background  

  • to book seats, and find out more information, British travellers should visit the FCO’s Pakistan Travel Advice; return to the UK page on GOV.UK
  • the charter flights are for UK travellers who normally reside in the UK and their direct dependants. Seats will be reserved for those deemed vulnerable
  • movement within Pakistan is restricted. Those who are eligible to fly will be advised to follow travel advice for transport to airports. They will be sent travel itineraries directly when their seat is confirmed
  • details regarding luggage allowance, flight costs and carriers will be available on the booking portal  
  • the price of a ticket for each flight is between £498-£522
  • the British High Commission continues to provide consular support to any British nationals who remain in Pakistan. Consular helpline numbers: +92 (0)51 201 2000
  • details of the ten previously announced charter flights are here

Further information

Follow the British High Commission Islamabad: